38
16
46
Cat. No. | Product Name | Target | Signaling Pathways |
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T38332 |
Complement factor D-IN-2
|
Complement System | Immunology/Inflammation |
Complement factor D-IN-2 是 omplement factor D 的有效抑制剂,在替代补体途径的早期和关键时刻靶向 factor D 并抑制补体级联反应。Complement factor D-IN-2在自身免疫疾病的方面有研究的价值。 | |||
T38803 | Factor D inhibitor 6 | ||
Factor D inhibitor 6 is a potent, highly selective, orally active compound that specifically inhibits the activity of factor D (FD). It demonstrates an IC50 of 30 nM and a Kd of 6 nM. Notably, Factor D inhibitor 6 does not exhibit any inhibitory effects against factor B, classical and lectin complement-pathway activation, nor does it interfere with a broad array of receptors, ion channels, kinases, and proteases. | |||
T19750 |
Spinosad Factor D
|
||
Spinosad Factor D is a naturally derived fermentation product. It is used as a pesticide against many different insects. | |||
T16898 |
Complement factor D-IN-1
|
Others | Others |
Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively). | |||
T39275 |
Befotertinib
D-0316,Befotertinib |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Befotertinib (D-0316) 是一种 EGFR 酪氨酸激酶抑制剂,可用于 EGFR T790M 阳性非小细胞肺癌的研究。 | |||
T9537 |
N'-Nitro-D-arginine
N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid,N'-硝基-D-精氨酸 |
Others | Others |
N'-Nitro-D-arginine (N'-Nitro-D-arginine) 是一种砌块。 | |||
T8496 |
MAZ51
|
Apoptosis; VEGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
MAZ51 是一种 VEGFR-3酪氨酸激酶的选择性抑制剂。它抑制 VEGF-C 诱导的 VEGFR-3 激活,而没有阻断 VEGF-C 介导的 VEGFR2 刺激。它阻止增殖并诱导多种肿瘤细胞凋亡,具有抗肿瘤活性。 | |||
T21867 |
BI-6015
2-甲基-1-(2-甲基-5-硝基苯基磺酰基)-1H-苯并[D]咪唑 |
Others | Others |
BI 6015 是肝细胞核因子 4α (HNF4α) 拮抗剂,可抑制已知 HNF4α 靶基因的表达。它利用 HNF4α 拮抗作用,降低胰岛素启动子活性,可用于研究癌症和糖尿病。 | |||
T13568L |
BCX 1470 hydrochloride
BCX 1470 hydrochloride(217099-43-9 Free base),BCX1470 HCl |
Serine Protease; Complement System | Immunology/Inflammation; Proteases/Proteasome |
BCX 1470 hydrochloride 是一种高效的丝氨酸蛋白酶抑制剂,具有抗炎活性,能抑制 factor D 和 C1s 的酯水解和溶血活性,可用于研究水肿。 | |||
T8509 |
Danicopan
ACH-4471 |
Complement System | Immunology/Inflammation |
Danicopan (ACH-4471) 是一种可口服的小分子 D 因子选择性抑制剂,对人 D 因子具有高结合亲和力,Kd 值为 0.54 nM。 它可抑制补体替代途径 (APC) 的活性,具有阻断阵发性夜间血红蛋白尿 (PNH) 和非典型溶血性尿毒症综合征 (aHUS) 的补体替代途径的潜力。 | |||
T10896L |
CSRM617 hydrochloride
CSRM617 hydrochloride(787504-88-5 Free base) |
Apoptosis; Others; Androgen Receptor | Apoptosis; Endocrinology/Hormones; Others |
CSRM617 hydrochloride 是转录因子ONECUT2(OC2,雄激素受体 AR 的主要调节剂) 的选择性小分子抑制剂,在 SPR 测定中Kd 为 7.43 uM,直接与 OC2-HOX 结构域结合。CSRM617 hydrochloride 通过裂解 Caspase-3 和 PARP 诱导细胞凋亡 (apoptosis)。CSRM617 hydrochloride 在小鼠的前列腺癌模型中具有良好的耐受性。 | |||
T39493 |
Vemircopan
ACH0145228,ACH-5228,ALXN2050 |
||
Vemircopan is a complement factor D inhibitor. | |||
T13568 |
BCX 1470
|
Serine Protease | Proteases/Proteasome |
BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively. | |||
T78424 |
CH3OCO-D-CHA-Gly-Arg-pNA acetate
|
Factor Xa | Metabolism |
CH3OCO-D-CHA-Gly-Arg-pNA acetate是一种用于检测factor Xa活性的显色底物。 | |||
T13567 |
BCX 1470 methanesulfonate
|
Serine Protease | Proteases/Proteasome |
BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively. | |||
T10644 |
c-Fms-IN-10
|
Others | Others |
c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, a kinase inhibitor of FMS (Colony-stimulating factor-1 receptor, CSF-1R; IC50: 2 nM) with anti-tumor activity. | |||
T76814 | Lampalizumab | ||
Lampalizumab (RG 7417) 为靶向补体通路中补体因子 D (Factor D) 的人源单克隆抗体。通过结合外位点,该药物立体阻断因子 B 进入活性位点,用于老年性黄斑变性 (AMD) 研究。 | |||
T80095 |
D-Pro-Phe-Arg-Chloromethylketone
|
Factor Xa | Metabolism |
D-Pro-Phe-Arg-Chloromethylketone是一种抑制剂,它针对凝血因子XII (coagulation factor XII) 和血浆激肽释放酶 (kallikrein),在血栓形成和炎症过程中具有关键作用。 | |||
T11269 |
FD-IN-1
|
Others | Others |
FD-IN-1 is a factor D (FD) inhibitor with an IC50 of 12 nM.FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5μM, respectively. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. | |||
T74422 | Sozinibercept | ||
Sozinibercept (OPT 302; VGX-300) 是VEGFR-3的可溶性形式,能有效抑制血管生成原因子VEGF-C/D 的活性,抑制血管生成和血管渗漏。Sozinibercept 对大鼠糖尿病视网膜水肿也有抑制作用。 | |||
T62020 | Pelecopan | ||
Pelecopan (BCX9930) 是有效的、选择性的口服补体因子D 抑制剂 (IC50= 14.3 nM)。Pelecopan 可以预防PNH 中的血管内和血管外溶血。 | |||
T77219 |
N-((Allyloxy)carbonyl)-N-methyl-L-alanine
|
||
N-((Allyloxy)carbonyl)-N-methyl-L-alanine 是一种丙氨酸衍生物。N-((Allyloxy)carbonyl)-N-methyl-L-alanine 可用于合成补体因子 D (complementfactor D) 抑制剂。补体因子 D 抑制剂可用于免疫系统相关疾病的研究。 | |||
TP2121 |
Sauvagine
|
||
Corticotropin-releasing factor (CRF) receptor agonist. Ki values are 9.4, 9.9, and 3.8 nM for inhibition of 125I-[D-Tyr1]astressin binding to hCRF-R1, rCRF-R2a and mCRF-R2b respectively. | |||
T76602 |
(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)
|
||
(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) 作为一种CRF拮抗剂,能有效阻断IL-1a诱发的黄体生成素 (LH) 抑制作用。 | |||
T78039 |
Acetyl-(D-Arg2)-GRF (1-29) amide (human)
|
||
Acetyl-(D-Arg2)-GRF (1-29) amide (human) 是一种针对人体的生长激素释放因子(GRF)拮抗剂,其主要作用是抑制生长激素(GH)的释放,广泛应用于内分泌学领域的研究。 | |||
T38045 |
Cholesterol β-D-Glucoside
|
||
Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose . It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It activates heat shock transcription factor 1 (Hsf1) in response to heat shock, which increases the expression of heat shock protein 70 (Hsp70) in TIG-3 human fetal lung fibroblasts when used at a concentration of 10 μM. Cholesterol β-D-glucoside (100 mg/kg) prevents ulcer formation following cold-restraint stress and increases Hsf1 activity... | |||
T83549 |
(D-Ala2)-GRF (1-29) amide (human)
|
||
'(D-Ala2)-GRF (1-29) amide (human)' 为一种GRF的超激动剂,其GH释放活性在猪和大鼠体内极为显著,大约为GRF (1-29)活性的50倍。 | |||
TP2121L |
Sauvagine acetate(74434-59-6 Free base)
|
||
Sauvagine acetate(74434-59-6 Free base) 是一种促肾上腺皮质激素释放因子 (CRF) 受体激动剂。 抑制 125I-[D-Tyr1]astressin 与 hCRF-R1、rCRF-R2a 和 mCRF-R2b 结合的 Ki 值分别为 9.4、9.9 和 3.8 nM。 | |||
T78003 |
[D-p-Cl-Phe6,Leu17]-VIP TFA
|
||
[D-p-Cl-Phe6,Leu17]-VIP TFA,为竞争性及选择性血管活性肠肽(VIP)受体拮抗剂,其IC50为125.8 nM。该化合物针对胰高血糖素、促胰液素和GRF受体均不表现活性。 | |||
T37079 |
VEGFR2 Kinase Inhibitor II
|
||
Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2's kinase activity (IC50 = 70 nM). It less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ; IC50 = 920 nM) and related receptor and non-receptor tyrosine kinases. V... | |||
T35933 |
D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt),Ins(1,4,5,6)-P4 |
||
D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.[1] D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal tran... | |||
T21920 |
UMB-32
|
||
UMB-32 是一种有效的选择性BRD4抑制剂,结合 BRD4 的Kd 为 550 nM,IC50为 637 nM。UMB-32 还显示出对TAF1的效力,TAF1是一种含溴结构域的转录因子。 | |||
T81571 |
PACAP (1-38) free acid TFA
|
||
PACAP (1-38) free acid TFA,一种内源性神经肽,能有效促进胃窦运动,增强体液蛋白分泌,同时抑制胃泌素释放。此外,它刺激血管活性肠肽、胃泌素释放肽和P物质的释放,并通过RACK1增强N-甲基-D-天门冬氨酸受体功能及脑源性神经营养因子表达。 | |||
T78165 | SPEN inhibitor 1 | Others | Others |
SPEN-IN-1(compound X1)是一种针对蛋白因子SPEN的抑制剂,其Kd值达47 nM。该化合物对于RepA显示出高度的选择性,RepA为Xist(非编码RNA原型)中包含431个核苷酸的结构域,由8.5个GC-rich基序构成,这些基序参与基因的沉默作用。 | |||
T81572 |
PACAP (1-38) free acid
|
||
PACAP (1-38) free acid 是一种具有多重生物功能的内源性神经肽,主要作用包括刺激胃窦运动、增进体液蛋白分泌、抑制胃泌素分泌,以及促进血管活性肠肽、胃泌素释放肽和P 物质的释放。此外,PACAP (1-38) free acid 通过与RACK1互作,可以增强N-甲基-D-天门冬氨酸受体的功能并促进脑源性神经营养因子的表达。 | |||
T36643 |
PKI-166 hydrochloride
|
||
Potent EGFR-kinase inhibitor (IC50 = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and orally bioavailable. Bruns et al (2000) Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 60 2926 PMID:10850439 |Ulu et al (2013) Epidermal ... | |||
T37736 |
N-cis-hexadec-9Z-enoyl-L-Homoserine lactone
N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone |
||
Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of whic... | |||
T37741 |
N-hexadecanoyl-L-Homoserine lactone
C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone |
||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3913 |
Saikosaponin D
|
Estrogen Receptor/ERR; NF-κB; Antibacterial; STAT | Endocrinology/Hormones; JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells |
Saikosaponin D 是一种从柴胡中分离到的三萜皂苷类天然产物,具有抗炎,抗菌,抗肿瘤,抗过敏作用。它抑制 selectin,STAT3和 NF-kB 的活性,活化estrogen receptor-β。 | |||
T5701 |
OPHIOPOGONIN D
麦冬皂苷 D,麦冬皂苷D |
RAAS; Calcium Channel; NF-κB; PPAR | DNA Damage/DNA Repair; Endocrinology/Hormones; Membrane transporter/Ion channel; Metabolism; NF-κB |
Ophiopogonin D 是从麦冬的块茎中分离的一种天然产物,是罕见的天然存在的 C29甾体糖苷。它是一种 CYP2J3 诱导剂,用于炎症和心血管疾病的相关研究。 | |||
T4518 |
Licochalcone D
|
ERK; NF-κB | MAPK; NF-κB |
Licochalcone D 是一种 NF-κB p65的有效抑制剂,是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物,具有抗氧化、抗炎、抗癌等作用。 | |||
T2775 |
Baicalin
黄芩苷,黄岑苷,Baicalein 7-O-β-D-glucuronide |
NF-κB; HIV Protease; GABA Receptor; Autophagy | Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome |
Baicalin (Baicalein 7-O-β-D-glucuronide) 是一种从黄芩中分离出来的脯氨酰内肽酶抑制剂,具有抗氧化、抗肿瘤、抗 HIV 的特性。 | |||
T2203 |
D-Carnitine hydrochloride
(S)-Carnitine Hydrochloride,L-Carnitine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride) 已被用于研究麦角硫因素转运蛋白 SLC22A4 和肉毒碱转运蛋白 SLC22A5,也被用于使棕榈酸进入线粒体。 | |||
TN6796 |
2'-FUCOSYLLACTOSE
2'-Fucosyl-D-lactose,2'-岩藻糖基乳糖 |
Others | Others |
2'-FUCOSYLLACTOSE (2'-Fucosyl-D-lactose) 是一种含岩藻糖的寡糖。 | |||
T19768 |
γ-Tocotrienol
gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol,γ-生育三烯酚 |
Others | Others |
γ-Tocotrienol (Plastochromanol) 是一种维生素 E 的活性形式。 | |||
TN4222 |
Homoeriodictyol 7-O-β-D-glucoside
高圣草素-7-O-Β-D-葡萄糖苷,Homoeriodictyol 7-O-glucoside |
Others; Platelet aggregation | Others |
Homoeriodictyol 7-O-β-D-glucoside (Homoeriodictyol 7-O-glucoside) 是 Viscum coloratum(Kom.)Nakai 的天然产物。Homoeriodictyol 7-O-β-D-glucoside 是血小板活化因子 (PAF) 的拮抗剂。 | |||
T2S0504 |
Ilexoside D
|
Others | Others |
Ilexoside D has ant-allergic, and anti-coagulant activities, it shows anti-tissue factor activity as well as the antithrombotic activity. | |||
T10086 |
24-Hydroxycholesterol
Cholest-5-ene-3beta,24-diol |
Liver X Receptor; NMDAR | Metabolism; Neuroscience |
24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) 是一种氧甾醇化合物,是一种 n-甲基-d-天门冬氨酸受体 (NMDA) 和转录因子 LXR 的激活剂,可用于研究心血管生成和胰腺癌。 | |||
T6480 |
D-Pantothenic acid
vitamin B5,pantothenate,D-泛酸 |
Others | Others |
D-Pantothenic acid (vitamin B5) 是必需的微量营养素,是辅酶 A 的前体,在很多生物过程中发挥关键作用,如调节碳水化合物,脂质,蛋白和核酸代谢。 | |||
T27191 |
D-Mannuronic Acid
|
||
D-Mannuronic Acid is a blocker of the TLR2 and TLR4 downstream signaling pathway. D-Mannuronic Acid effectively inhibits mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB. | |||
T40832 |
Ferulic acid acyl-β-D-glucoside
Ferulic acid glucoside,Ferulic acid acyl-β-D-glucoside |
||
Ferulic acid acyl-β-D-glucoside, a metabolite of Ferulic Acid, is a novel inhibitor of fibroblast growth factor receptor 1 (FGFR1). It exhibits IC50 values of 3.78 µM and 12.5 µM for FGFR1 and FGFR2, respectively. | |||
T41139 |
Echinocystic acid 28-O-β-D-glucoside
|
||
Echinocystic acid 28-O-β-D-glucoside is a metabolite resulting from the microbial oxidation and glucosidation of Echinocystic acid. It exhibits inhibitory activity towards the tissue factor pathway, with an IC50 value measured at 10.61 nM. | |||
TN3706 |
Coronarin A
|
||
Coronarin, A, B, C, and D are cytotoxic prinicples from the rhizomes of Hedychium coronarium, Zingiberaceae. Coronarin A exhibits good growth inhibition activities on HUVEC proliferation, it effectively suppresses the growth factor induced tube formation | |||
TN4664 |
Norarmepavine
|
Others | Others |
N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)- N-norarmepavine exhibits significa |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02183 |
Complement Factor D/CFD Protein, Human, Recombinant (His)
PFD,DF,complement factor D |
Human | HEK293 Cells |
Complement Factor D/CFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.8 kDa and the accession number is P00746. | |||
TMPY-01008 |
VEGFD Protein, Human, Recombinant (His)
VEGFD,c-fos induced growth fa... |
Human | HEK293 Cells |
VEGFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O43915. | |||
TMPH-03272 |
Complement factor D Protein, Rat, Recombinant (His)
Adipsin,Df,Adn,C3 convertase acti... |
Rat | P. pastoris (Yeast) |
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. | |||
TMPJ-00149 |
Complement Factor D/CFD Protein, Mouse, Recombinant (His)
C3 convertase activator,28 kDa adipocyte p... |
Mouse | HEK293 Cells |
Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3, which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the... | |||
TMPK-00151 |
Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)
C3 convertase activator,AMBP-1,PFD,FACTOR ... |
Mouse | HEK293 Cells |
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Mouse, Recom... | |||
TMPK-00755 |
Complement Factor D/CFD Protein, Human, Recombinant (hFc)
C3 convertase activator,DF,AMBP-1,EC 3.4.21,EC 3.4.... |
Human | HEK293 Cells |
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Human, Recom... | |||
TMPH-03271 |
Complement factor D Protein, Rat, Recombinant (His & Myc)
Adn,C3 convertase activator,Properdin ... |
Rat | HEK293 Cells |
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 29.8 kDa and the accession number is P32038. | |||
TMPK-00671 |
Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)
Adipsin,CFD,ADN,Complement fa... |
Rhesus | HEK293 Cells |
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Rhesus macaq... | |||
TMPY-02167 |
Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293)
DF,Adn,complement factor D |
Mouse | HEK293 Cells |
Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.4 kDa and the accession number is P03953-2. | |||
TMPY-00072 |
GITR/TNFRSF18 Protein, Human, Recombinant (His)
AITR,GITR-D,tumor necrosis factor receptor... |
Human | HEK293 Cells |
GITR/TNFRSF18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3. | |||
TMPY-03150 |
VEGFD Protein, Mouse, Recombinant (His)
VEGF-D,Vegfd,AI325264,c-fos induc... |
Mouse | HEK293 Cells |
VEGFD Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14 kDa and the accession number is P97946. | |||
TMPY-02589 |
VEGFD Protein, Mouse, Recombinant (hFc)
c-fos induced growth factor (vasc... |
Mouse | HEK293 Cells |
VEGFD Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.6 kDa and the accession number is P97946. | |||
TMPY-03200 |
VEGFD Protein, Rat, Recombinant (hFc)
c-fos induced growth factor (vasc... |
Rat | HEK293 Cells |
VEGFD Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.6 kDa and the accession number is O35251. | |||
TMPY-05602 |
GITR/TNFRSF18 Protein, Human, Recombinant (hFc & Avi), Biotinylated
AITR,GITR,tumor necrosis factor receptor superfamil... |
Human | HEK293 Cells |
GITR/TNFRSF18 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 43.1 kDa and the accession number is Q9Y5U5-3. | |||
TMPY-05233 |
GITR/TNFRSF18 Protein, Human, Recombinant (His), Biotinylated
GITR-D,CD357,AITR,GITR,tumor necrosis ... |
Human | HEK293 Cells |
GITR/TNFRSF18 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3. | |||
TMPY-04265 |
GITR/TNFRSF18 Protein, Human, Recombinant (hFc)
GITR-D,tumor necrosis factor receptor supe... |
Human | HEK293 Cells |
GITR/TNFRSF18 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.5 kDa and the accession number is Q9Y5U5-1. | |||
TMPY-06411 |
GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated
CD357,GITR-D,tumor necrosis factor |
Human | HEK293 Cells |
GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.79 kDa and the accession number is Q9Y5U5-3. | |||
TMPJ-01040 |
MAX Protein, Human, Recombinant (His)
Protein Max,MAX,bHLHd4,Myc-Associated ... |
Human | E. coli |
Myc-Associated Factor X (MAX) is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It contains 1 basic helix-loop-helix (bHLH) domain. It is found in the brain, heart, and lung at high levels while lower levels are seen in the liver, kidney, and skeletal muscle. MAX forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MA... | |||
TMPJ-00072 |
IL-18BPd Protein, Mouse, Recombinant (hFc)
Interleukin 18 Binding Protein Isoform d,I... |
Mouse | HEK293 Cells |
Interleukin 18 binding protein (IL-18BP) is a physiological inhibitor that acts through binding to the receptor-binding site of IL-18. IL-18 stimulates INF-γ, which then stimulates 18BP production via NF-κB. The interaction between IL-18 and IL-18BP has a significant role in the inflammation process. IL-18 BPs have four isoforms, a, b, c and d, which are spliced by different ways. The IL-18 BP isoforms a and c each contain one immunoglobulin (Ig)-like C2-type domain which is essential to the bin... | |||
TMPJ-00110 |
GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His)
Tnfrsf18,GITR-D,CD357,AITR,Tumor necrosis ... |
Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and... | |||
TMPY-02732 |
ARMET/MANF Protein, Mouse, Recombinant (His)
AA408789,AA673178,D17914,D18Mgi17,mesencep... |
Mouse | HEK293 Cells |
ARMET/MANF Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.6 kDa and the accession number is Q9CXI5. | |||
TMPY-04548 |
CDK4 Protein, Human, Recombinant (GST)
CMM3,PSK-J3,cyclin-dependent kinase 4 |
Human | Baculovirus Insect Cells |
CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser... | |||
TMPY-01442 |
DMBT1 Protein, Human, Recombinant (His)
GP340,deleted in malignant brain tumors 1,... |
Human | HEK293 Cells |
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo... | |||
TMPK-01178 |
PDGFD Protein, Cynomolgus, Recombinant (His)
IEGF,SCDGFB,PDGF-D,SCDGF... |
Cynomolgus | HEK293 Cells |
Platelet‑derived growth factor D (PDGF‑D) is a new member of the PDGF family that binds the PDGFR‑β homodimer. PDGF‑D promotes the angiogenic capacity of EPCs, including proliferation, migration, adhesion and tube formation, and thereby contributes to angiogenesis. | |||
TMPH-02607 |
Complement factor B Protein, Mouse, Recombinant (His)
C3/C5 convertase,Complement factor B,Cfb,Bf,H2-Bf |
Mouse | E. coli |
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. | |||
TMPK-00722 |
DDT Protein, Mouse, Recombinant (His)
DDCT,D-dopachrome tautom... |
Mouse | E. coli |
D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum at similar concentrations as MIF. D-DT binds the MIF cell surface receptor complex, CD74/CD44, with high affinity and induces similar cell signaling and effector functions. DDT Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predict... | |||
TMPK-01307 |
DDT Protein, Cynomolgus, Recombinant (His)
MIF2,D-dopachrome decarboxylase,<... |
Cynomolgus | E. coli |
D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum at similar concentrations as MIF. D-DT binds the MIF cell surface receptor complex, CD74/CD44, with high affinity and induces similar cell signaling and effector functions. DDT Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with N-His tag. The pr... | |||
TMPK-01257 |
DDT Proten, Canine, Recombinant (His)
EC 4.1.1.84,DDCT,D-DT,MI... |
Canine | E. coli |
D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum at similar concentrations as MIF. D-DT binds the MIF cell surface receptor complex, CD74/CD44, with high affinity and induces similar cell signaling and effector functions. DDT Proten, Canine, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predict... | |||
TMPK-00864 |
DDT Protein, Human, Recombinant (His)
Phenylpyruvate tautomerase II,D-dopachrome... |
Human | E. coli |
D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily.The D-DT protein also is present in most tissues and circulates in serum at similar concentrations as MIF. D-DT binds the MIF cell surface receptor complex, CD74/CD44, with high affinity and induces similar cell signaling and effector functions. DDT Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predict... | |||
TMPH-03206 |
ITGB8 Protein, Rabbit, Recombinant (His & Myc)
|
Rabbit | E. coli |
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Required during vasculogenesis. ITGB8 Protein, Rabbit, Recombinant (His & Myc) is expressed in E. coli ... | |||
TMPJ-01043 |
PHS Protein, Human, Recombinant (His)
4-Alpha-Hydroxy-Tetrahydropterin D |
Human | E. coli |
Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type ... | |||
TMPH-03038 |
Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)
Cobra venom factor,Complement C3 homolog,CVFk,CVF |
Naja kaouthia | E. coli |
Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely re... | |||
TMPY-03868 |
ARF5 Protein, Human, Recombinant (His)
ARF5,ADP ribosylation factor 5 |
Human | E. coli |
ARF5, also known as ADP-ribosylation factor 5, belongs to the small GTPase superfamily, Arf family. Members of this family stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. ARF5 functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. ARF5 Is involved in protein trafficking. ARF5 may also modulate vesicle budding and uncoating within the Golgi apparatus. | |||
TMPK-00420 |
PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated
RHEPDGFRA,PDGFRA,PDGF R α/PD<... |
Human | HEK293 Cells |
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. There are four members of PDGF family known as PDGF-A chain, PDGF-B chain, PDGF-C chain and PDGF-D chain, which in active forms are dimers. As far as two receptors PDGF-alpha R and PDGF-beta R are known to bind PDGF. PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-... | |||
TMPK-00943 |
PDGF R alpha/PDGFRA Protein, Cynomolgus, Recombinant (His)
PDGF R α/PDGFRA Protein, Cynomolgus, Recom... |
Cynomolgus | HEK293 Cells |
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. There are four members of PDGF family known as PDGF-A chain, PDGF-B chain, PDGF-C chain and PDGF-D chain, which in active forms are dimers. As far as two receptors PDGF-alpha R and PDGF-beta R are known to bind PDGF. PDGF R alpha/PDGFRA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predic... | |||
TMPK-01378 |
IL-12B Protein, Cynomolgus, Recombinant (His)
CLMF2,NKSF2,CLMF,CLMF p40,IL-12B,IL-12 subunit p40,NKS |
Cynomolgus | HEK293 Cells |
Interleukin (IL)‑12B, which encodes the p40 subunit common to IL‑12 and IL‑23, as one of the genes for which expression in fibroblast‑like synoviocytes from patients with rheumatoid arthritis (RA‑FLS) is induced by DcR3.Decoy receptor 3 (DcR3) competitively binds to three ligands, Fas ligand, lymphotoxin‑related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells and tumor necrosis factor‑like ligand 1A (TL1A), to prevent their effects. Recent studi... | |||
TMPK-00419 |
PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi)
RHEPDGFRA,PDGFR-2,CD140A,PD |
Human | HEK293 Cells |
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. There are four members of PDGF family known as PDGF-A chain, PDGF-B chain, PDGF-C chain and PDGF-D chain, which in active forms are dimers. As far as two receptors PDGF-alpha R and PDGF-beta R are known to bind PDGF. PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The p... | |||
TMPY-03796 |
ARF3 Protein, Human, Recombinant (His)
ADP-ribosylation factor 3 |
Human | E. coli |
ARF3, also known as ADP-ribosylation factor 3, belongs to the RAS superfamily. Members of this family include ARF1, ARF2, ARF3, ARF4, ARF5 and ARF6. ARF3 gene is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. ARF3 functions as an allosteric activator of the cholera toxin subunit, an ADP-ribosyltrans... | |||
TMPJ-00376 |
IL-17RD Protein, Human, Recombinant (hFc)
IL17Rhom,IL17RD,IL-17RD,IL-17 RD,... |
Human | HEK293 Cells |
Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation ... | |||
TMPJ-00936 |
CCND2 Protein, Human, Recombinant (His)
G1/S-specific cyclin-D2,CCND2 |
Human | E. coli |
CCND2,also known as G1/S-specific cyclin-D2,is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such ... | |||
TMPY-02765 |
GM2A Protein, Human, Recombinant (His)
GM2 ganglioside activator,SAP-3,GM2-AP |
Human | Baculovirus Insect Cells |
GM2A (GM2 ganglioside activator), is a lipid transfer protein which belongs to the ML domain family. GM2A can accommodate several single chain phospholipids and fatty acids. It also exhibits some calcium-independent phospholipase activity. GM2A binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. GM2A acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexo... | |||
TMPY-03509 |
TCTP/TPT1 Protein, Human, Recombinant (His)
tumor protein, translationally-controlled 1,HRF,TCT... |
Human | E. coli |
Tumor protein, also known as TPT1, is a highly conserved protein among many eukaryotic organisms. Tumor protein is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TPT1) (or P23) is a protein that has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first... | |||
TMPY-04542 |
CDK2 Protein, Human, Recombinant (His)
CDKN2,cyclin-dependent kinase 2,p... |
Human | Baculovirus Insect Cells |
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c... | |||
TMPH-02173 |
TRBC2 Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracell... | |||
TMPH-02168 |
TRAC Protein, Human, Recombinant (E. coli, His)
|
Human | E. coli |
Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracel... | |||
TMPH-02169 |
TRBC1 Protein, Human, Recombinant (His)
|
Human | P. pastoris (Yeast) |
Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracell... |